Cardiomagnyl during pregnancy28.06.2022
Cardiomagnyl is a complex preparation that contains:
- acetylsalicylic acid ( aspirin );
- magnesium sulfate .
The therapeutic effect of Cardiomagnyl is the action of acetylsalicylic acid on the blood, and the magnesium salt is added to the drug in order to protect the stomach from its damaging effects. Cardiomagnyl is prescribed to pregnant women for the treatment of preeclampsia and other complications.
Preeclampsia is a serious complication of pregnancy that occurs after the 20th week of gestation. Main symptoms: increased blood pressure, combined with the presence of protein in the urine.
The doctor may prescribe any of the aspirin preparations in the required dose to the pregnant woman, namely:
- Aspirin Cardio.
There is no significant difference which trade name of acetylsalicylic acid to take.
What does Cardiomagnyl prevent?
According to the latest international recommendations, aspirin is used to prevent two of the most serious complications of pregnancy, pre-eclampsia and subsequent eclampsia , as well as additional risks to the mother and fetus associated with them.
Eclampsia is a disease that occurs during pregnancy and childbirth, which is an extreme degree of manifestation of severe complications of pregnancy. It is expressed by seizures, loss of consciousness and convulsions that occur against the background of vasospasm and circulatory disorders in the internal organs.
If risk factors for early preeclampsia are identified in the first trimester of pregnancy, it is most effectively prevented by starting aspirin from 11-20 weeks.
Also, an obstetrician-gynecologist may prescribe aspirin to support pregnancy in IVF cycles and with recurrent miscarriage.
Taking Cardiomagnyl (aspirin) has potential risks. It can increase bleeding in a pregnant woman, as well as in the fetus (since it crosses the placental barrier).
Doctors used to think that taking aspirin during the first trimester of pregnancy could increase the risk of certain birth defects. In recent years, large studies have shown that taking low doses of aspirin is relatively safe and has a positive effect on preventing severe complications in mother and child.
How does Cardiomagnyl work?
Although the exact cause of pre-eclampsia is unknown, scientists have linked its development in a pregnant woman to impaired kidney function. The increase in pressure, the appearance of large amounts of protein in the urine and edema in preeclampsia support this hypothesis.
According to another version, preeclampsia develops due to clotting and poor blood circulation in the arteries of the placenta.
In any case, aspirin in the composition of Cardiomagnyl thins the blood, slowing down the appearance of platelets (microthrombi from blood cells) . Better blood flow allows the kidneys and placenta to be more fully supplied with blood, thereby improving their functioning. This prevents or at least slows down the development of preeclampsia.
Benefits for mother and fetus
The discovery that something as simple as taking aspirin (the active ingredient in Cardiomagnyl) prophylactically during pregnancy was practically a revolution in the prevention of preeclampsia.
This severe disease, which affects 2-5% of pregnant women, has always been one of the main causes of maternal and infant mortality during pregnancy. Every year, 76,000 women and 500,000 babies die from this disease worldwide.
Timely treatment with the correct dose of aspirin reduces the incidence of preeclampsia before 32 weeks of gestation by 60-90% (depending on the severity of risk factors).
In other cases, such treatment slows down the development of preeclampsia and shifts it to later stages of pregnancy. Since the main goal of treating preeclampsia is to prevent it from progressing to eclampsia, which is deadly for the woman (early induced labor), this delay is vital for the baby.
Prescribing low doses of aspirin (for example, as in Cardiomagnyl) reduces the likelihood that a newborn will need intensive care by 68%, that is, more than 2 times.
How to understand if you need to take Cardiomagnyl during pregnancy
All pregnant women should be screened for early preeclampsia during the first trimester of pregnancy.
The International Federation of Obstetrics and Gynecology (FIGO) is calling on all countries and their member associations to promote strategies to ensure testing for early preeclampsia in the first trimester of pregnancy.
Screening is simple and is carried out using a one-stage combined test that takes into account:
- maternal risk factors;
- mean arterial pressure (MAP);
- serum placental growth factor (PLGF);
- uterine artery pulsation index (UTPI).
The risk calculator is available free of charge from the FIGO website .
If a doctor has determined that a pregnant woman is at high risk of developing early preeclampsia, taking low doses of aspirin (eg, Cardiomagnyl) is highly desirable.
What doses of Cardiomagnyl are used during pregnancy
Different studies used different doses of aspirin: 50, 60, 75 (the amount of aspirin in 1 cardiomagnyl tablet), 100 and 150 mg/day. Naturally, the higher the dose, the more likely it is that side effects (bleeding, stomach pain) will occur.
However, the preventive effect of aspirin against preeclampsia also depends on the dose – the higher it is, the better the effect. Therefore, if the risk is assessed by the calculator as significant, then the required dose is 150 mg of aspirin (two Cardiomagnyl tablets) at night.
Research shows that starting treatment plays a big role in preventing preeclampsia. The recommended time to start taking aspirin is between 16 and 24 weeks of pregnancy. It is necessary to continue taking until the 36th week of pregnancy.
An important detail: taking aspirin at night provides more benefit and prevention of preeclampsia compared to taking it in the morning.
- Rolnik DL, Nicolaides KH, Poon LC Prevention of preeclampsia with aspirin. \ Am J Obstet Gynecol. 2022;226(2S):S1108-S1119, PubMed .
- Poon LC, Shennan A., Hyett JA, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention \ Int J Gynaecol Obstet. 2019;145(Suppl 1):1-33, NCBI .
- Ahrens KA, Silver RM, Mumford SL, et al. Complications and Safety of Preconception Low-Dose Aspirin Among Women With Prior Pregnancy Losses. \ Obstet Gynecol. 2016;127(4):689-698, NCBI .
- Akhigbe RE The role of low-dose aspirin in the prevention of pre-eclampsia. \ Niger Med J. 2014;55(1):86, NCBI .
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